Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth
نویسندگان
چکیده
Jiajun Zhu1,2,3, Morgan A. Sammons1,2, Greg Donahue1,2, Zhixun Dou1,2, Masoud Vedadi4,5, Matthaeus Getlik6, Dalia Barsyte-Lovejoy4, Rima Al-Awar5,6, Bryson W. Katona7, Ali Shilatifard8, Jing Huang9, Xianxin Hua7, Cheryl H. Arrowsmith4,10, and Shelley L. Berger1,2,11 1Cell and Developmental Biology, University of Pennsylvania 2Epigenetics Program, University of Pennsylvania 3Biomedical Graduate Studies, University of Pennsylvania 4Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada 5Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada
منابع مشابه
p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines.
A bidirectional expression vector that allowed equal transcription of cloned wild-type and mutant p53 cDNAs from the same vector was developed. The vector was transfected into CaLu 6 lung carcinoma cells or Saos-2 osteosarcoma cells. All p53 mutants examined were recessive to wild-type p53 transactivation of p21(WAF1/CIP1) but dominant-negative for transactivation of Bax. An examination of effe...
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عنوان ژورنال:
دوره 525 شماره
صفحات -
تاریخ انتشار 2015